Not Chopped Liver-A Careful, Fate-Mapping Study of Macrophages in NASH.

Moreno-Fernandez, Maria E; Miraldi, Emily R; Divanovic, Senad · Cell Metab · 2020

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Abstract

Macrophages are central to the pathogenesis of non-alcoholic steatohepatitis (NASH). However, the identities and functional relationships between tissue-resident and tissue-recruited macrophages in NASH remain poorly understood. A recent study from Seidman et al. (2020) elucidates, at single-cell resolution, the fates, niches, and regulatory landscapes of liver tissue-resident and tissue-recruited macrophage populations in NASH.

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