An Antibody Attack against Body Wasting in Cancer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32877689.
- Also identified by DOI 10.1016/j.cmet.2020.08.003.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Cachexia is a devastating, non-curable condition in many cancer patients that is marked by severe wasting of the muscle and fat tissue. Its prevention has been hampered by an insufficient knowledge of the underlying molecular mechanism(s) that lead to its pathogenesis. Suriben et al. (2020) now report the development and characterization of an antagonistic antibody for the previously identified GDF15-GFRAL axis that efficiently blocks tumor-induced body wasting in experimental animals.
Medical subject headings
- Cachexia
- Neoplasms