Lung-targeting lentiviral vector for passive immunisation against influenza.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32883885.
- Also identified by DOI 10.1136/thoraxjnl-2020-214656 and PMC identifier 7677466.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
When recombinant simian immunodeficiency virus (SIV) is pseudotyped with the F and HN glycoproteins from murine respiratory Sendai virus (rSIV.F/HN), it provides efficient lung cell targeting and lifelong transgene expression in the murine airways. We have shown that a single dose of rSIV.F/HN can direct stable expression of neutralising antibody against influenza in the murine airways and systemic circulation, and protects mice against two different influenza strains in lethal challenge experiments. These data suggest that rSIV.F/HN could be used as a vector for passive immunisation against influenza and other respiratory pathogens.
Medical subject headings
- Antibodies, Neutralizing
- Genetic Vectors
- Influenza A Virus, H1N1 Subtype
- Lung
- Orthomyxoviridae Infections
- Simian Immunodeficiency Virus