Lesson of the month: novel method to quantify neutrophil uptake in early lung cancer using SPECT-CT.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32887739.
- Also identified by DOI 10.1136/thoraxjnl-2020-214642 and PMC identifier 7569370.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Neutrophils play an important role in the lung tumour microenvironment. We hypothesised that radiolabelled neutrophils coupled to single-photon emission CT (SPECT) may non-invasively quantify neutrophil uptake in tumours from patients with non-small cell lung cancer. We demonstrated increased uptake of radiolabelled neutrophils from the blood into tumours compared with non-specific uptake using radiolabelled transferrin. Moreover, indium-111-neutrophil activity in the tumour biopsies also correlated with myeloperoxidase (MPO)-positive neutrophils. Our data support the utility of imaging with In-111-labelled neutrophils and SPECT-CT to quantify neutrophil uptake in lung cancer.
Medical subject headings
- Lung Neoplasms
- Neutrophils
- Tomography, Emission-Computed, Single-Photon