Revealing Instability: Genetic Variation Underlies Variability in mESC Pluripotency.
editorial · Level V
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- Record sourced from PubMed, PMID 32888420.
- Also identified by DOI 10.1016/j.stem.2020.08.012.
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Abstract
mESCs can self-renew indefinitely in vitro. However, depending on culture conditions some strains are more unstable than others. In this issue of Cell Stem Cell, Skelly et al. (2020) and Ortmann et al. (2020) shed light into the role genetic variation plays in control of ground state pluripotency.
Medical subject headings
- Mouse Embryonic Stem Cells
- Pluripotent Stem Cells