Straight to the X: Modeling Human X Chromosome Inactivation in hESCs by FGF Signal Blockade.
editorial · Level V
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- Record sourced from PubMed, PMID 32888422.
- Also identified by DOI 10.1016/j.stem.2020.08.008.
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Abstract
In this issue of Cell Stem Cell, An et al. (2020) provide a model to study human X chromosome inactivation. They followed X chromosome activity and traced cellular heterogeneity in naive hESCS, showed that it is caused by incomplete blockade of FGF-signaling, and in doing so isolated cells resembling pre-implantation epiblasts.
Medical subject headings
- Human Embryonic Stem Cells
- X Chromosome Inactivation