Identification of immunodominant linear epitopes from SARS-CoV-2 patient plasma.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32903266.
- Also identified by DOI 10.1371/journal.pone.0238089 and PMC identifier 7480855.
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Abstract
A novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) is the source of a current pandemic (COVID-19) with devastating consequences in public health and economic stability. Using a peptide array to map the antibody response of plasma from healing patients (12) and heathy patients (6), we identified three immunodominant linear epitopes, two of which correspond to key proteolytic sites on the spike protein (S1/S2 and S2') known to be critical for cellular entry. We show biochemical evidence that plasma positive for the epitope adjacent to the S1/S2 cleavage site inhibits furin-mediated proteolysis of spike.
Medical subject headings
- Coronavirus Infections
- Epitopes
- Pneumonia, Viral