Direct measurement of forces between cell-coating polymers and chiral crystal surfaces: the enantioselectivity of.
basic_science · Level V
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- Record sourced from PubMed, PMID 32907120.
- Also identified by DOI 10.1039/b717940e.
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Abstract
The interactions of hyaluronan (HA), a high-molecular-weight linear polysaccharide present in many pericellular coatings, with different facets of chiral calcium tartrate (CT) crystal surfaces are investigated using a molecular force probe. Forces between {011} and {110} facets of (R,R) and (S,S) CT crystals and a HA-bearing surface have been measured in saturated CT solutions. It has been observed that hyaluronan binds most strongly to the {011} facet of the (R,R) crystal, compared with the other facets examined, which is consistent with earlier observations of the adhesion of HA-coated cells to chiral CT crystals. The variation of binding strength among the facets studied is tentatively attributed to the surface structure difference between the {011} and {110} facets as well as to the preferential matching of the local hyaluronan H-bond network to the -OH groups on the {011} facet of the (R,R) enantiomer.