The NEMP family supports metazoan fertility and nuclear envelope stiffness.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32923640.
- Also identified by DOI 10.1126/sciadv.abb4591 and PMC identifier 7455189.
- Licence recorded as CC BY-NC.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Human genome-wide association studies have linked single-nucleotide polymorphisms (SNPs) in <i>NEMP1</i> (<i>nuclear envelope membrane protein 1</i>) with early menopause; however, it is unclear whether NEMP1 has any role in fertility. We show that whole-animal loss of NEMP1 homologs in <i>Drosophila</i>, <i>Caenorhabditis elegans</i>, zebrafish, and mice leads to sterility or early loss of fertility. Loss of Nemp leads to nuclear shaping defects, most prominently in the germ line. Biochemical, biophysical, and genetic studies reveal that NEMP proteins support the mechanical stiffness of the germline nuclear envelope via formation of a NEMP-EMERIN complex. These data indicate that the germline nuclear envelope has specialized mechanical properties and that NEMP proteins play essential and conserved roles in fertility.