An Antioxidant Enzyme Therapeutic for COVID-19.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32924219.
- Also identified by DOI 10.1002/adma.202004901.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The COVID-19 pandemic has taken a significant toll on people worldwide, and there are currently no specific antivirus drugs or vaccines. Herein it is a therapeutic based on catalase, an antioxidant enzyme that can effectively breakdown hydrogen peroxide and minimize the downstream reactive oxygen species, which are excessively produced resulting from the infection and inflammatory process, is reported. Catalase assists to regulate production of cytokines, protect oxidative injury, and repress replication of SARS-CoV-2, as demonstrated in human leukocytes and alveolar epithelial cells, and rhesus macaques, without noticeable toxicity. Such a therapeutic can be readily manufactured at low cost as a potential treatment for COVID-19.
Medical subject headings
- Anti-Inflammatory Agents
- Antioxidants
- Betacoronavirus
- Catalase
- Coronavirus Infections
- Pneumonia, Viral