Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Avidity Maturation and Association with Disease Severity.

Luo, Yiqi Ruben; Chakraborty, Indrani; Yun, Cassandra; Wu, Alan H B; Lynch, Kara L · Clin Infect Dis · 2021

prospective_cohort · Level II

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Abstract

The kinetics of IgG avidity maturation during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was studied. The IgG avidity assay, using a novel label-free immunoassay technology, revealed a strong correlation between IgG avidity and days since symptom onset. Peak readings were significantly higher in severe than mild disease cases.

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