A shared genetic contribution to breast cancer and schizophrenia.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 32934226.
- Also identified by DOI 10.1038/s41467-020-18492-8 and PMC identifier 7492262.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
An association between schizophrenia and subsequent breast cancer has been suggested; however the risk of schizophrenia following a breast cancer is unknown. Moreover, the driving forces of the link are largely unclear. Here, we report the phenotypic and genetic positive associations of schizophrenia with breast cancer and vice versa, based on a Swedish population-based cohort and GWAS data from international consortia. We observe a genetic correlation of 0.14 (95% CI 0.09-0.19) and identify a shared locus at 19p13 (GATAD2A) associated with risks of breast cancer and schizophrenia. The epidemiological bidirectional association between breast cancer and schizophrenia may partly be explained by the genetic overlap between the two phenotypes and, hence, shared biological mechanisms.
Medical subject headings
- Breast Neoplasms
- GATA Transcription Factors
- Schizophrenia