Lewis Blood-group Antigens Are Associated With Altered Susceptibility to Shigellosis.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 32940644.
- Also identified by DOI 10.1093/cid/ciaa1409 and PMC identifier 8315233.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
In a cohort of infants, we found that lack of the Lewis histo-blood group antigen was associated with increased susceptibility to shigellosis. Broadly inhibiting fucosylation in epithelial cells in vitro decreased invasion by Shigella flexneri. These results support a role for fucosylated glycans in susceptibility to shigellosis.
Medical subject headings
- Dysentery, Bacillary