Association of a genetic risk score with BMI along the life-cycle: Evidence from several US cohorts.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 32941506.
- Also identified by DOI 10.1371/journal.pone.0239067 and PMC identifier 7497990.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We use data from the National Longitudinal Study of Adolescent to Adult Health and from the Health and Retirement Study to explore how the effect of individuals' genetic predisposition to higher BMI -measured by BMI polygenic scores- changes over the life-cycle for several cohorts. We find that the effect of BMI polygenic scores on BMI increases significantly as teenagers transition into adulthood (using the Add Health cohort, born 1974-83). However, this is not the case for individuals aged 55+ who were born in earlier HRS cohorts (1931-53), whose life-cycle pattern of genetic influence on BMI is remarkably stable as they move into old-age.
Medical subject headings
- Obesity