Plasmodium vivax Strains Use Alternative Pathways for Invasion.
basic_science · Level V
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- Record sourced from PubMed, PMID 32941614.
- Also identified by DOI 10.1093/infdis/jiaa592 and PMC identifier 8161644.
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Abstract
Plasmodium vivax has 2 invasion ligand/host receptor pathways (P. vivax Duffy-binding protein/Duffy antigen receptor for chemokines [DARC] and P. vivax reticulocyte binding protein 2b/transferrin receptor [TfR1]) that are promising targets for therapeutic intervention. We optimized invasion assays with isogenic cultured reticulocytes. Using a receptor blockade approach with multiple P. vivax isolates, we found that all strains utilized both DARC and TfR1, but with significant variation in receptor usage. This suggests that P. vivax, like Plasmodium falciparum, uses alternative invasion pathways, with implications for pathogenesis and vaccine development.
Medical subject headings
- Antigens, CD
- Duffy Blood-Group System
- Malaria, Vivax
- Plasmodium vivax
- Receptors, Cell Surface
- Receptors, Transferrin