A Metabolic Bottleneck for Stem Cell Transformation.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 32946778.
- Also identified by DOI 10.1016/j.cell.2020.08.038 and PMC identifier 7861329.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Although oncogenic mutations predispose tissue stem cells to tumor initiation, the rate-limiting processes for stem cell immortalization remain unknown. In this issue of Cell, Bonnay et al. identify enhanced electron transport chain activity as a critical determinant of this process, establishing metabolic reprogramming as limiting for tumor initiation.
Medical subject headings
- Cell Transformation, Neoplastic
- Neural Stem Cells