cAMP Signaling in Nanodomains.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32946779.
- Also identified by DOI 10.1016/j.cell.2020.08.041.
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Abstract
Cyclic-3',5'-adenosine monophosphate (cAMP) is an ancient second messenger but organizing signaling selectivity on the nanoscale is poorly understood. Examining transport of a new fluorescent cAMP probe, Bock and coworkers observe "buffered diffusion" and establish phosphodiesterase activity can organize cAMP nanodomains, while Zhao and coworkers find that protein kinase A regulatory subunits assemble liquid droplets to further localize cAMP signaling.
Medical subject headings
- Cyclic AMP
- Cyclic AMP-Dependent Protein Kinases