Prokaryotic Argonautes Function beyond Immunity by Unlinking Replicating Chromosomes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32946780.
- Also identified by DOI 10.1016/j.cell.2020.08.037.
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Abstract
Eukaryotic Argonaute proteins strictly mediate RNA-guided RNA interference. In contrast, prokaryotic Argonautes can utilize DNA guides to target complementary DNA sequences to protect their hosts against invading DNA. In this issue of Cell, Jolly and colleagues demonstrate that Thermus thermophilus Argonaute additionally participates in DNA replication by unlinking catenated chromosomes.
Medical subject headings
- Argonaute Proteins
- Thermus thermophilus