Severe Acute Respiratory Syndrome Coronavirus 2 Spreads to Lymph Nodes and Strongly Expands CD4+ Effector Memory RA Cells in a Patient With Mild Coronavirus Disease 2019.

Roldán-Santiago, Ernesto; Benito-Berlinches, Amparo; Martínez-García, Laura; Quereda, Carmen; Rodríguez-Martín, Eulalia; Pérez-Elías, Pilar; López-Pintor, Jose María; Walo-Delgado, Paulette Esperanza et al. · Clin Infect Dis · 2021

case_report · Level V

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Abstract

A woman with mild coronavirus disease 2019 developed cervical adenopathy, being diagnosed of Epstein-Barr virus infectious mononucleosis. We performed fine needle aspiration, and demonstrate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is found in lymph nodes even in mild disease along with a strong expansion of terminally differentiated effector memory CD4+ T cells, a cell population that is practically absent in lymph nodes.

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