Genetic Risk of Alzheimer's Disease and Sleep Duration in Non-Demented Elders.
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- Record sourced from PubMed, PMID 32951248.
- Also identified by DOI 10.1002/ana.25910 and PMC identifier 8048405.
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Abstract
Growing evidence has suggested an association between sleep duration and Alzheimer's disease (AD), but it is unclear if sleep duration is a manifestation of the AD disease process. We studied whether genetic liability for AD predicts sleep duration using a genetic risk score (GRS) for AD (AD-GRS), in 406,536 UK Biobank participants with European ancestry and without dementia at enrollment. Higher AD-GRS score was associated with shorter sleep (b = -0.014, 95% confidence interval [CI] = -0.022 to -0.006), especially in those aged 55+. Using AD-GRS as an instrumental variable for AD diagnosis, incipient AD reduced sleep duration by 1.87 hours (95% CI = 0.96, 2.78). Short sleep duration might be an early marker of AD. ANN NEUROL 2021;89:177-181.
Medical subject headings
- Alzheimer Disease
- Genetic Predisposition to Disease
- Sleep