Stereolithographic fabrication of three-dimensional permeable scaffolds from CaP/PEGDA hydrogel biocomposites for use as bone grafts.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32957218.
- Also identified by DOI 10.1016/j.jmbbm.2020.103922.
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Abstract
Polyethylene glycol diacrylate-based hydrogels filled with calcium phosphates (CaP, Ca/P < 1.5) were stereolithographically fabricated as three-dimensional permeable biocomposites for bone tissue regeneration, probed by several instrumental techniques (including scanning electron microscopy, infrared and UV-vis spectroscopy), and subjected to rheological/mechanical property analysis. As the CaP content increased from 0 to 10 wt%, Young's modulus and mechanical strength increased from 4 to 11 kPa and from 34 to 167 kPa, respectively. Moreover, the enhanced elastic properties and tuneable swelling behaviour of the fabricated composites made them well suited for bone defect filling.
Medical subject headings
- Hydrogels
- Tissue Scaffolds