Response to Anti-PD-1 in Microsatellite-Stable Colorectal Cancer: A STAT Need.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 32958701.
- Also identified by DOI 10.1158/1078-0432.CCR-20-2901.
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Abstract
Most colorectal cancers are microsatellite-stable with no response to anti-PD-1 therapy, necessitating the development of new immunomodulatory treatment strategies. Coinhibition of anti-PD-1 and STAT3 can elicit an effective antitumor response in a small subset of patients with microsatellite-stable colorectal cancer, and biomarkers predictive of response are under investigation.<i>See related article by Kawazoe et al., p. 5887</i>.
Medical subject headings
- Colorectal Neoplasms
- Microsatellite Instability