Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults.
meta_analysis · Level I
Where this comes from
- Record sourced from PubMed, PMID 32963231.
- Also identified by DOI 10.1038/s41467-020-18367-y and PMC identifier 7508833.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There is enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging.
Medical subject headings
- Aging
- Brain
- Genome-Wide Association Study
- Mental Disorders
- Neurodegenerative Diseases