The changes of the peripheral CD4+ lymphocytes and inflammatory cytokines in Patients with COVID-19.
cross_sectional · Level IV
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- Record sourced from PubMed, PMID 32976531.
- Also identified by DOI 10.1371/journal.pone.0239532 and PMC identifier 7518571.
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Abstract
To investigate the clinical value of changes in the subtypes of peripheral blood lymphocytes and levels of inflammatory cytokines in patients with COVID-19, the total numbers of lymphocytes and CD4+ lymphocytes and the ratio of CD4+/CD8+ lymphocytes were calculated and observed in different groups of patients with COVID-19. The results show that the lymphocytopenia in patients with COVID-19 was mainly manifested by decreases in the CD4+ T lymphocyte number and the CD4+/CD8+ ratio. The decreased number of CD4+ T lymphocytes and the elevated levels of TNF-α and IL-6 were correlated with the severity of COVID-19 disease.
Medical subject headings
- CD4-Positive T-Lymphocytes
- Coronavirus Infections
- Cytokines
- Pneumonia, Viral