Routine Early Antibiotic Use in SymptOmatic Preterm Neonates: A Pilot Randomized Controlled Trial.

Ruoss, J Lauren; Bazacliu, Catalina; Russell, Jordan T; Cruz, Diomel de la; Li, Nan; Gurka, Matthew J; Filipp, Stephanie L; Polin, Richard A et al. · J Pediatr · 2021

rct · Level II

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Abstract

We enrolled 98 infants (gestational age <33 weeks) in a pilot randomized trial of antibiotics vs no antibiotics; 55 were randomized (lower maternal infectious risk; symptoms expected for gestation). Adverse events did not differ significantly between the randomization arms. This trial establishes a framework for a larger multicentered trial.

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