Emerging RNA-Dependent RNA Polymerase Mutation in a Remdesivir-Treated B-cell Immunodeficient Patient With Protracted Coronavirus Disease 2019.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 32986807.
- Also identified by DOI 10.1093/cid/ciaa1474 and PMC identifier 7543308.
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Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly discovered virus for which remdesivir is the only antiviral available. We report the occurrence of a mutation in RdRP (D484Y) following treatment with remdesivir in a 76-year-old female with post-rituximab B-cell immunodeficiency and persistent SARS-CoV-2 viremia. A cure was achieved after supplementation with convalescent plasma.
Medical subject headings
- COVID-19
- RNA-Dependent RNA Polymerase
- COVID-19 Drug Treatment