DNA Methylation Profiling of Premalignant Lesions as a Path to Ovarian Cancer Early Detection.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32988966.
- Also identified by DOI 10.1158/1078-0432.CCR-20-3331.
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Abstract
Genome-wide DNA methylation profiles of serous tubal intraepithelial carcinomas (STIC) resemble methylation profiles of high-grade serous ovarian carcinomas (HGSOC) more closely than normal fallopian tube epithelium. While STICs and HGSOCs share subsets of common hypermethylated regions, DNA methylation can distinguish STICs from HGSOCs to provide proof-of-principle that DNA methylation can identify HGSOC initiation.<i>See related article by Pisanic et al., p. 6310</i>.
Medical subject headings
- Cystadenocarcinoma, Serous
- Fallopian Tube Neoplasms
- Ovarian Neoplasms