Photo-controlled degradation of PLGA/Ti<sub>3</sub>C<sub>2</sub> hybrid coating on Mg-Sr alloy using near infrared light.
basic_science · Level V
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- Record sourced from PubMed, PMID 32995680.
- Also identified by DOI 10.1016/j.bioactmat.2020.08.013 and PMC identifier 7501411.
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Abstract
A PLGA/Ti<sub>3</sub>C<sub>2</sub> hybrid coating was successfully deposited on the surface of magnesium-strontium (Mg-Sr) alloys. Compared with the corrosion current density (<i>i</i> <sub><i>corr</i></sub> ) of the Mg-Sr alloy (7.13 × 10<sup>-5</sup> A/cm<sup>2</sup>), the modified samples (Mg/PLGA/Ti<sub>3</sub>C<sub>2</sub>) was lower by approximately four orders of magnitude (7.65 × 10<sup>-9</sup> A/cm<sup>2</sup>). After near infrared 808 nm laser irradiation, the <i>i</i> <sub><i>corr</i></sub> of the modified samples increased to 3.48 × 10<sup>-7</sup> A/cm<sup>2</sup>. The mechanism is that the local hyperthermia induced the free volume expansion of PLGA, and the increase in intermolecular gap enhanced the penetration of electrolytes. Meanwhile, the cytotoxicity study showed that the hybrid coating endowed the Mg-Sr alloy with enhanced biocompatibility.