Targeting PIs to improve PTs:a new approach to treating genetic diseases of the proximal tubule.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32998810.
- Also identified by DOI 10.1016/j.kint.2020.06.018.
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Abstract
Defective recycling of megalin consequent to impaired phosphatidylinositol metabolism has been implicated as a mechanism causing tubular proteinuria in patients with Lowe syndrome. In this issue, Berquez et al. describe an innovative approach using a clinically approved drug to "rebalance" phosphatidylinositols and restore megalin traffic in mouse and cell models of the disease.
Medical subject headings
- Kidney Tubules, Proximal
- Low Density Lipoprotein Receptor-Related Protein-2