Interleukin-12 Message in a Bottle.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 33004432.
- Also identified by DOI 10.1158/1078-0432.CCR-20-3250.
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Abstract
IL12 is a very potent cancer immunotherapy agent, but is difficult to harness safely if given systemically. Local gene transfer aims to confine the effects of IL12 to malignant tissues, thus avoiding toxicity. Lipid-nanoparticle mRNA achieves IL12 expression and efficacy in mouse models, opening the way to an ongoing trial.<i>See related article by Hewitt et al., p. 6284</i>.
Medical subject headings
- Interleukin-12
- Neoplasms