Defining the First Part of the Oncogenic KRAS Journey.
editorial · Level V
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- Record sourced from PubMed, PMID 33007229.
- Also identified by DOI 10.1016/j.stem.2020.09.009.
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Abstract
Discovered as a proto-oncogene 40 years ago, mutations in KRAS exist in ∼30% of all human cancers. In this issue of Cell Stem Cell,Dost et al. (2020) combine the power of analyzing organoid cultures, patient samples, and mouse models with scRNA-seq to elucidate early events occurring with oncogenic KRAS activation.
Medical subject headings
- Proto-Oncogene Proteins
- ras Proteins