One Ring to Rule Them All: Mitochondrial Circular RNAs Control Mitochondrial Function.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 33007261.
- Also identified by DOI 10.1016/j.cell.2020.09.028 and PMC identifier 12135702.
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Abstract
Circular RNAs (circRNAs) have emerged as key regulators of a wide variety of biological processes, but the roles of mitochondrial circRNAs are largely unknown. In this issue of Cell, Zhao et al. (2020) reveal that mitochondrial DNA-encoded circRNAs interact with ATP synthase subunit β (ATP5B) to inhibit the output of mitochondrial reactive oxygen species and the activation of liver fibroblasts, which regulate the pathogenesis of liver disease.
Medical subject headings
- Non-alcoholic Fatty Liver Disease
- RNA, Circular