BRCA1 and PALB2 in a Messy Breakup.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 33008804.
- Also identified by DOI 10.1158/0008-5472.CAN-20-2731.
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Abstract
Mutations in the <i>BRCA1</i> gene cause an extremely high lifetime risk of breast and ovarian cancer, but the exact mechanism by which the BRCA1 protein acts to prevent cancer onset remains unclear. In this edition of <i>Cancer Research</i>, Park and colleagues describe a new mouse model featuring a single amino acid substitution in the coiled-coil motif of BRCA1. This change prevents BRCA1 from interacting with PALB2 (partner and localizer of BRCA2), causing rapid cancer onset and a loss of blood cells similar to Fanconi anemia.<i>See related article by Park et al., p. 4172</i>.
Medical subject headings
- BRCA1 Protein
- Fanconi Anemia