Progress Toward Cardiac Xenotransplantation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 33017208.
- Also identified by DOI 10.1161/CIRCULATIONAHA.120.048186 and PMC identifier 7990044.
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Abstract
Consistent survival of life-supporting pig heart xenograft recipients beyond 90 days was recently reported using genetically modified pigs and a clinically applicable drug treatment regimen. If this remarkable achievement proves reproducible, published benchmarks for clinical translation of cardiac xenografts appear to be within reach. Key mechanistic insights are summarized here that informed recent pig design and therapeutic choices, which together appear likely to enable early clinical translation.
Medical subject headings
- Graft Survival
- Heart
- Heart Transplantation