Deep brain optogenetics without intracranial surgery.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 33020604.
- Also identified by DOI 10.1038/s41587-020-0679-9 and PMC identifier 7878426.
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Abstract
Achieving temporally precise, noninvasive control over specific neural cell types in the deep brain would advance the study of nervous system function. Here we use the potent channelrhodopsin ChRmine to achieve transcranial photoactivation of defined neural circuits, including midbrain and brainstem structures, at unprecedented depths of up to 7 mm with millisecond precision. Using systemic viral delivery of ChRmine, we demonstrate behavioral modulation without surgery, enabling implant-free deep brain optogenetics.
Medical subject headings
- Brain
- Optogenetics