Where Mitochondria Meet Autoimmunity: The Treg Cell Link.
Level V
Where this comes from
- Record sourced from PubMed, PMID 33027671.
- Also identified by DOI 10.1016/j.cmet.2020.08.006.
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Abstract
Although a crucial role for mitochondrial metabolism in controlling T regulatory (Treg) cell function has been recognized, its contribution during autoimmunity has not yet been fully elucidated. In this issue of Cell Metabolism, Alissafi and colleagues demonstrate that during autoimmunity, Treg cell functional alterations associate with mitochondrial oxidative stress, dysfunctional mitophagy, and enhanced DNA damage response, culminating with their cell death.
Medical subject headings
- Autoimmunity
- T-Lymphocytes, Regulatory