Language of a Long-Term Relationship: Bacterial Inositols and the Intestinal Epithelium.
Level V
Where this comes from
- Record sourced from PubMed, PMID 33027672.
- Also identified by DOI 10.1016/j.cmet.2020.09.015.
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Abstract
The exact principles guiding host-microbe homeostasis in the intestinal tract remain obscure. In a recent issue of Nature, Wu et al. (2020) describe that bacterial-derived inositols are an important principle that shapes regenerative properties of the colonic epithelium. The metabolites activate HDAC3, which represents an important part of the epigenetic machinery.
Medical subject headings
- Gastrointestinal Microbiome