ACE2 mouse models: a toolbox for cardiovascular and pulmonary research.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 33057007.
- Also identified by DOI 10.1038/s41467-020-18880-0 and PMC identifier 7560817.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Angiotensin-converting enzyme 2 (ACE2) has been identified as the host entry receptor for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for the COVID-19 pandemic. ACE2 is a regulatory enzyme of the renin-angiotensin system and has protective functions in many cardiovascular, pulmonary and metabolic diseases. This review summarizes available murine models with systemic or organ-specific deletion of ACE2, or with overexpression of murine or human ACE2. The purpose of this review is to provide researchers with the genetic tools available for further understanding of ACE2 biology and for the investigation of ACE2 in the pathogenesis and treatment of COVID-19.
Medical subject headings
- Cardiovascular Diseases
- Disease Models, Animal
- Lung Diseases
- Peptidyl-Dipeptidase A