Two Cases With Features of Lymphocyte Variant Hypereosinophilic Syndrome With STAT3 SH2 Domain Mutations.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 33060403.
- Also identified by DOI 10.1097/PAS.0000000000001604.
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Abstract
Lymphocyte variant hypereosinophilic syndrome (LV-HES) is a rare cause of eosinophilia that is due to eosinophilipoietic cytokine production by an immunophenotypically abnormal T-cell clone. The molecular pathogenesis of this disorder is largely unknown and only 1 case of LV-HES with a pathogenic STAT3 mutation has been described thus far. Here we report 2 cases of LV-HES with STAT3 SH2 domain mutations. These cases further support the model that activation of STAT3 signaling through STAT3 SH2 domain mutations is a recurrent event in LV-HES.
Medical subject headings
- Hypereosinophilic Syndrome
- STAT3 Transcription Factor
- T-Lymphocytes
- src Homology Domains