Risk Factor Profiles Can Distinguish Esophageal Adenocarcinoma From Barrett's Esophagus.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 33065588.
- Also identified by DOI 10.14309/ajg.0000000000001001.
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Abstract
It is assumed that screening risk factors for Barrett's esophagus (BE) and prevalent esophageal adenocarcinoma (EAC) are the same. A matched case-control study comparing risk factors between EAC and BE was performed. In 1,356 patients (678 with EAC and 678 with BE), heartburn (52.7%), diabetes, hyperlipidemia, hypertension, nonalcoholic steatohepatitis, and metabolic syndrome were less common in EAC (52.7, 29.2, 45.7, 48.2, 12, and 28.5%, resp.) compared with BE (84.5, 37.6, 82.2, 64.6, 18.4, and 44.1%, P < 0.01). Mean alanine aminotransferase and HgA1c levels were also significantly lower in EAC compared with BE. Optimal strategies for screening for prevalent EAC may be different than that for BE.
Medical subject headings
- Adenocarcinoma
- Barrett Esophagus
- Diabetes Mellitus
- Esophageal Neoplasms
- Gastroesophageal Reflux
- Heartburn
- Metabolic Syndrome