Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 33087721.
- Also identified by DOI 10.1038/s41467-020-19146-5 and PMC identifier 7577971.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The CR3022 antibody, selected from a group of SARS-CoV monoclonal antibodies for its ability to cross-react with SARS-CoV-2, has been examined for its ability to bind to the ectodomain of the SARS-CoV-2 spike glycoprotein. Using cryo-electron microscopy we show that antibody binding requires rearrangements in the S1 domain that result in dissociation of the spike.
Medical subject headings
- Antibodies, Monoclonal
- Antibodies, Viral
- Betacoronavirus
- Binding Sites, Antibody
- Spike Glycoprotein, Coronavirus