Impaired inhibitory processing: a new therapeutic target for autism and psychosis?
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 33092656.
- Also identified by DOI 10.1192/bjp.2020.163 and PMC identifier 7612604.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In the healthy brain, homeostatic balance between excitation and inhibition maintains neural stability. Reduced inhibition may explain shared symptoms observed in autism and psychosis. Here we review evidence suggesting that altered levels of gamma-aminobutyric acid (GABA) may underlie both disorders, providing a potential cross-diagnostic therapeutic target.
Medical subject headings
- Autism Spectrum Disorder
- Autistic Disorder
- Psychotic Disorders