Achalasia Is Associated With Atopy in Patients Younger Than 40 Years of Age.
case_control · Level III
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- Record sourced from PubMed, PMID 33105192.
- Also identified by DOI 10.14309/ajg.0000000000001006.
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Abstract
Case reports describe individuals with achalasia features subsequently diagnosed with eosinophilic esophagitis (an atopic disorder). We have examined associations between achalasia and atopic and autoimmune conditions. This is a UK cohort study of 2,593 subjects with achalasia matched to 10,402 controls. At diagnosis, achalasia was associated with autoimmune conditions (odds ratio 1.39; 95% confidence interval 1.02-1.90) and atopic conditions (1.40; 1.00-1.95) in those aged younger than 40 years. Our findings support an autoimmune etiology in achalasia but also suggest a possible atopic etiology in younger subjects.
Medical subject headings
- Autoimmune Diseases
- Esophageal Achalasia
- Hypersensitivity
- Neurodegenerative Diseases