Checking the Hippo in Sarcomatoid Renal Cell Carcinoma with Immunotherapy.

Hwang, Joyce K; Agarwal, Neeraj; Brugarolas, James; Zhang, Tian · Clin Cancer Res · 2021

editorial · Level V

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Abstract

Subset analysis of patients with sarcomatoid renal cell carcinoma (sRCC) included in the CheckMate 214 trial of ipilimumab-nivolumab versus sunitinib showed improved outcomes in sRCC with ipilimumab-nivolumab. The use of checkpoint inhibitor-based regimens in sRCC, for which therapeutic options were once limited, is further supported by additional clinical trials.<i>See related article by Tannir et al., p. 78</i>.

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