The S-phase-induced lncRNA <i>SUNO1</i> promotes cell proliferation by controlling YAP1/Hippo signaling pathway.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 33108271.
- Also identified by DOI 10.7554/eLife.55102 and PMC identifier 7591261.
- Licence recorded as CC0.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Cell cycle is a cellular process that is subject to stringent control. In contrast to the wealth of knowledge of proteins controlling the cell cycle, very little is known about the molecular role of lncRNAs (long noncoding RNAs) in cell-cycle progression. By performing genome-wide transcriptome analyses in cell-cycle-synchronized cells, we observed cell-cycle phase-specific induction of >2000 lncRNAs. Further, we demonstrate that an S-phase-upregulated lncRNA, <i>SUNO1</i>, facilitates cell-cycle progression by promoting YAP1-mediated gene expression. <i>SUNO1</i> facilitates the cell-cycle-specific transcription of <i>WTIP</i>, a positive regulator of YAP1, by promoting the co-activator, DDX5-mediated stabilization of RNA polymerase II on chromatin. Finally, elevated <i>SUNO1</i> levels are associated with poor cancer prognosis and tumorigenicity, implying its pro-survival role. Thus, we demonstrate the role of a S-phase up-regulated lncRNA in cell-cycle progression <i>via</i> modulating the expression of genes controlling cell proliferation.
Medical subject headings
- Cell Proliferation
- Co-Repressor Proteins
- Cytoskeletal Proteins
- DEAD-box RNA Helicases
- Gene Expression Regulation
- RNA, Long Noncoding
- Signal Transduction