Age is in the Eye of the Beholder: Distinguishing Molecular Signatures in Early-onset Pancreatic Adenocarcinomas.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 33109735.
- Also identified by DOI 10.1158/1078-0432.CCR-20-3683.
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Abstract
Pancreatic ductal adenocarcinoma (PDAC) is more prevalent in older patients, but early-onset cases (<55 years) may be a distinct genetic subpopulation. Differential expression of CDKN2A and transcription factor FOXC2 were found in early-onset cases. This finding opens the door to investigating additional features that distinguish PDAC tumors in this age group.<i>See related article by Tsang et al., p. 246</i>.
Medical subject headings
- Adenocarcinoma
- Carcinoma, Pancreatic Ductal
- Pancreatic Neoplasms