T2 Mapping Values in Postmeniscectomy Knee Articular Cartilage after Running: Early Signs of Osteoarthritis?

Abstract

Loading on the joints during running may have a deleterious effect on post-partial meniscectomy knee cartilage, leading to osteoarthritis. Utilizing T2-mapping measurements before and after running may enable the observation of changes in the articular cartilage of the postmeniscectomy knees compared with healthy knees. After medial partial meniscectomy, 12 volunteers underwent magnetic resonance imaging (MRI) of the both knees, before and immediately after 30 minutes of running. Quantitative assessment of articular cartilage was performed using a T2-mapping technique. In the medial compartment of the operated knees, significantly lower T2 values were found in anterior tibial plateau (pre- vs. postrun: 33.85 vs. 30.45 ms; <i>p</i> = 0.003) and central tibial plateau (33.33 vs. 30.63 ms; <i>p</i> = 0.007). Similar differences were found in lateral regions of central femur (post- vs. prerun: 35.86 vs. 40.35 ms; <i>p</i> = 0.015), posterior femur (34.89 vs. 37.73 ms; <i>p</i> = 0.001), and anterior tibia (24.66 vs. 28.70 ms, <i>p</i> = 0.0004). In lateral compartment, postrun values were significantly lower in operated compared with healthy knees, in central femur (34.89 vs. 37.59 ms; <i>p</i> = 0.043), posterior femoral (36.88 vs. 39.36 ms; <i>p</i> = 0.017), anterior tibia (24.66 vs. 30.20 ms; <i>p</i> = 0.009), and posterior tibia (28.84 vs. 33.17 ms; <i>p</i> = 0.006). No statistical difference was found while comparing postrun to prerun healthy knees. Lower T2 values were found in operated knees after 30 minutes of running. These changes were seen in medial and lateral compartments. We suspect that running may subject the articular cartilage to excessive loads in the post-partial meniscectomy knee, loads that in healthy knee do not cause any changes.