The beneficial and pathogenic roles of complement in COVID-19.
Level V
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- Record sourced from PubMed, PMID 33115882.
- Also identified by DOI 10.3949/ccjm.87a.ccc065 and PMC identifier 8079550.
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Abstract
We briefly summarize the complement system and its functions in immunity and disease. We present data supporting the requirement of complement to resolve COVID-19, and discuss how complement overactivation later in severe disease could drive multiorgan damage characteristic of fatal COVID-19.