Bone From Blood: Characteristics and Clinical Implications of Circulating Osteogenic Progenitor (COP) Cells.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 33118647.
- Also identified by DOI 10.1002/jbmr.4204.
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Abstract
Circulating osteogenic progenitor (COP) cells are a population of cells in the peripheral blood with the capacity for bone formation, as well as broader differentiation into mesoderm-like cells in vitro. Although some of their biological characteristics are documented in vitro, their role in diseases of the musculoskeletal system remains yet to be fully evaluated. In this review, we provide an overview of the role of COP cells in a number of physiological and pathological conditions, as well as identify areas for future research. In addition, we suggest possible areas for clinical utilization in the management of musculoskeletal diseases. © 2020 American Society for Bone and Mineral Research (ASBMR).
Medical subject headings
- Osteogenesis
- Stem Cells