Genetic Inhibition of PCSK9 and Liver Function.

Rimbert, Antoine; Smati, Sarra; Dijk, Wieneke; Le May, Cédric; Cariou, Bertrand · JAMA Cardiol · 2021

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Abstract

This study investigates associations of the lifelong genetic inhibition of <i>PCSK9</i> with plasma liver enzymes and nonalcoholic fatty liver disease by using the loss-of-function variant <i>PCSK9</i>-p.Arg46Leu as a genetic instrument.

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